The one and only hotel I would recommend, located in the center of Mytilini town (Lesvos island), is called "The Tower of Mytilini". As you may see from the photos below, the rooms are traditionally decorated and some of them have an extraordinary view of the port. Besides, I have to point out that the breakfast is delicious as there is a variety of handmade delicacies.

The Tower of Mytilini Hotel
49, El. Venizelou Street
GR-81100 Mytilini
Lesvos, Greece
Tel: +30 22510 25069/27977
Fax: +30 22510 47319